Claudin 2 (CLDN2) Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P57739 |
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Other Accession | NP_065117 |
Clone Names | 6072343 |
Gene ID | 9075 |
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Other Names | Claudin-2, SP82, CLDN2 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6309a was selected from the N-term region of human CLDN2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CLDN2 |
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Function | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. |
Cellular Location | Cell junction, tight junction {ECO:0000250|UniProtKB:O88552}. Cell membrane {ECO:0000250|UniProtKB:O88552}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O88552} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Members of the claudin protein family, such as CLDN2, are expressed in an organ-specific manner and regulate the tissue-specific physiologic properties of tight junctions.
References
Morita,K., Proc. Natl. Acad. Sci. U.S.A. 96 (2), 511-516 (1999)Furuse,M., J. Cell Biol. 141 (7), 1539-1550 (1998)
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