TBRG1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q3YBR2 |
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Clone Names | 71213146 |
Gene ID | 84897 |
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Other Names | Transforming growth factor beta regulator 1, Nuclear interactor of ARF and Mdm2, TBRG1, NIAM |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6376c was selected from the Center region of human TBRG1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TBRG1 |
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Synonyms | NIAM |
Function | Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability. |
Cellular Location | Nucleus. |
Tissue Location | Widely expressed at low levels in most tissues, with highest levels in pancreas, lung and liver. Expression is decreased in primary tumors including lung, liver, breast, pancreas and kidney carcinomas, chronic lymphocytic leukemia and diffuse large B- cell lymphoma. |
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Provided below are standard protocols that you may find useful for product applications.
Background
TBRG1 acts as a growth inhibitor. It can activate TP53/p53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. It redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.
References
Tompkins,V.S., J. Biol. Chem. 282 (2), 1322-1333 (2007)Babalola,G.O.,Mol. Reprod. Dev. 41 (2), 133-139 (1995)
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