Drosophila DJ-1A (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | A1Z9J4 |
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Other Accession | Q9V6V5 |
Clone Names | 5070555 |
Gene ID | 36543 |
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Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6416a was selected from the C-term region of human Drosophila DJ-1A (C-term). A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DJ-1alpha {ECO:0000312|FlyBase:FBgn0033885} |
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Function | Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor (PubMed:16139213, PubMed:16139214, PubMed:20457924). Does not play a role in methylglyoxal detoxification (By similarity). |
Cellular Location | Cytoplasm. Nucleus. Mitochondrion |
Tissue Location | Expressed in testis (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
DJ-1 mutations are associated with rare forms of autosomal recessive early-onset Parkinson's disease (PD). DJ-1 is suggested to normally function as a redox-sensitive molecular chaperone protective against cellular oxidative stress. DJ-1 drosophila models are an important tool for elucidating protein function and for modeling neurodegenerative disease.
References
Moore DJ, et al. Sci Aging Knowledge Environ. 2006 Jan 11;2006(2):pe2.Park J, et al. Gene. 2005 Nov 21;361:133-9.Yang Y, et al. Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13670-5. Menzies FM, et al. Curr Biol. 2005 Sep 6;15(17):1578-82. Meulener M, et al. Curr Biol. 2005 Sep 6;15(17):1572-7. Meulener M, et al. J Neurochem. 2005 Jun;93(6):1524-32.
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