IL17RB Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9NRM6 |
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Clone Names | 81110105 |
Gene ID | 55540 |
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Other Names | Interleukin-17 receptor B, IL-17 receptor B, IL-17RB, Cytokine receptor-like 4, IL-17 receptor homolog 1, IL-17Rh1, IL17Rh1, Interleukin-17B receptor, IL-17B receptor, IL17RB, CRL4, EVI27, IL17BR |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6762c was selected from the Center region of human IL17RB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | IL17RB |
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Synonyms | CRL4, EVI27, IL17BR |
Function | Receptor for the pro-inflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells. |
Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein |
Tissue Location | Expressed in several endocrine tissues, mostly in fetal and adult liver, kidney, pancreas, testis, colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines |
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Provided below are standard protocols that you may find useful for product applications.
Background
IL17RB is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E.
References
Goetz,M.P., et.al., Clin. Cancer Res. 14 (18), 5864-5868 (2008)
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