HMGCS2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P54868 |
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Clone Names | 80513200 |
Gene ID | 3158 |
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Other Names | Hydroxymethylglutaryl-CoA synthase, mitochondrial, HMG-CoA synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, HMGCS2 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6793b was selected from the C-term region of human HMGCS2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | HMGCS2 |
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Function | Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate. |
Cellular Location | Mitochondrion {ECO:0000250|UniProtKB:P22791}. |
Tissue Location | Expression in liver is 200-fold higher than in any other tissue. Low expression in colon, kidney, testis, and pancreas Very low expression in heart and skeletal muscle (PubMed:7893153, PubMed:21952825, PubMed:16940161). Not detected in brain (PubMed:21952825). |
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Provided below are standard protocols that you may find useful for product applications.
Background
HMGCS2 belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting.
References
Lu,Y., et.al., J. Lipid Res. 49 (12), 2582-2589 (2008)
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