MTMR9 Antibody Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q96EF0 |
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Other Accession | NP_060147 |
Clone Names | 2020805 |
Gene ID | 55613 |
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Other Names | Myotubularin-related protein 8, 313-, MTMR8 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6808a was selected from the C-term region of human MTMR8 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | MTMR8 |
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Function | Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:22647598, PubMed:26143924). Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5- bisphosphate (PubMed:22647598, PubMed:26143924). In complex with MTMR9, negatively regulates autophagy (PubMed:22647598). |
Cellular Location | Nucleus envelope. |
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Provided below are standard protocols that you may find useful for product applications.
Background
MTMR8 is a myotubularin-related protein that is atypical to most other members of the myotubularin-related protein family because it has no dual-specificity phosphatase domain. The encoded protein contains a double-helical motif similar to the SET interaction domain, which is thought to have a role in the control of cell proliferation. In mouse, a protein similar to the encoded protein binds with MTMR7, and together they dephosphorylate phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate.
References
Appel, S., et al., Eur. J. Hum. Genet. 10(1):17-25 (2002).Appel, S., et al., Genomics 75 (1-3), 6-8 (2001).
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