TTF2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UNY4 |
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Clone Names | 81201026 |
Gene ID | 8458 |
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Other Names | Transcription termination factor 2, 364-, Lodestar homolog, RNA polymerase II termination factor, Transcription release factor 2, F2, HuF2, TTF2 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6813a was selected from the N-term region of human TTF2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TTF2 |
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Function | DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. |
Cellular Location | Cytoplasm. Nucleus. Note=Cytoplasmic during interphase Relocates to the nucleus as cells enter mitosis |
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Provided below are standard protocols that you may find useful for product applications.
Background
TTF2 is a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. This protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing.
References
Tonacchera,M., et.al., Thyroid 14 (8), 584-588 (2004)
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