ECE1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P42892 |
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Clone Names | 90504048 |
Gene ID | 1889 |
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Other Names | Endothelin-converting enzyme 1, ECE-1, ECE1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6855d was selected from the Center region of human ECE1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ECE1 |
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Function | Converts big endothelin-1 to endothelin-1. |
Cellular Location | Cell membrane; Single-pass type II membrane protein |
Tissue Location | All isoforms are expressed in umbilical vein endothelial cells, polynuclear neutrophils, fibroblasts, atrium cardiomyocytes and ventricles. Isoforms A, B and C are also expressed in placenta, lung, heart, adrenal gland and phaeochromocytoma; isoforms A and C in liver, testis and small intestine; isoform B, C and D in endothelial cells and umbilical vein smooth muscle cells; isoforms C and D in saphenous vein cells, and isoform C in kidney |
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Provided below are standard protocols that you may find useful for product applications.
Background
ECE-1 is involved in proteolytic processing of endothelin precursors to biologically active peptides.
References
Cottrell,G.S., et.al., J. Biol. Chem. 284 (33), 22411-22425 (2009)
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