TP53INP2/DOR Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8IXH6 |
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Clone Names | 90415006 |
Gene ID | 58476 |
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Other Names | Tumor protein p53-inducible nuclear protein 2, Diabetes and obesity-regulated gene, p53-inducible protein U, PIG-U, TP53INP2, C20orf110, DOR, PINH |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6960b was selected from the C-term region of human TP53INP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TP53INP2 |
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Synonyms | C20orf110, DOR, PINH |
Function | Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA. |
Cellular Location | Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re- localizes to autophagosomes on autophagy activation |
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Provided below are standard protocols that you may find useful for product applications.
Background
TP53INP2 is a scaffold protein that recruits LC3 and/or LC3-related proteins to the autophagosome membrane by interacting with the transmembrane protein VMP1.
References
Bennetts,J.S., et.al., Dev. Dyn. 236 (3), 843-852 (2007)
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