PANK3 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9H999 |
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Clone Names | 4012604 |
Gene ID | 79646 |
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Other Names | Pantothenate kinase 3, hPanK3, Pantothenic acid kinase 3, PANK3 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7161b was selected from the Center region of human PANK3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PANK3 |
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Function | Catalyzes the phosphorylation of pantothenate to generate 4'- phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. |
Cellular Location | Cytoplasm {ECO:0000269|PubMed:23152917, ECO:0000305} |
Tissue Location | Highly expressed in the liver. |
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Provided below are standard protocols that you may find useful for product applications.
Background
PANK3 belongs to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is expressed most abundantly in the liver.
References
Zhou, B., et al., Nat. Genet. 28(4):345-349 (2001).Robishaw, J.D., et al., Am. J. Physiol. 248 (1 PT 1), E1-E9 (1985) (): ().
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