ARSA Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P15289 |
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Clone Names | 80411127 |
Gene ID | 410 |
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Other Names | Arylsulfatase A, ASA, Cerebroside-sulfatase, Arylsulfatase A component B, Arylsulfatase A component C, ARSA |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7471b was selected from the C-term region of human ARSA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ARSA |
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Function | Hydrolyzes cerebroside sulfate. |
Cellular Location | Endoplasmic reticulum. Lysosome |
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Provided below are standard protocols that you may find useful for product applications.
Background
ARSA hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this protein lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death.
References
Stein C., Gieselmann V.J. Biol. Chem. 264:1252-1259(1989)Kreysing J.Eur. J. Biochem. 191:627-631(1990)Fujii T., Kobayashi T.Biochim. Biophys. Acta 1122:93-98(1992)Chen R., Jiang X.J. Proteome Res. 8:651-661(2009)Lukatela G., Krauss N.Biochemistry 37:3654-3664(1998)
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