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HS2ST1 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q7LGA3 |
|---|---|
| Other Accession | O93336, Q8R3H7, Q76KB1 |
| Gene ID | 9653 |
|---|---|
| Other Names | Heparan sulfate 2-O-sulfotransferase 1, 2-O-sulfotransferase, 2OST, 282-, HS2ST1, HS2ST, KIAA0448 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 185-200 of HUMAN HS2ST1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | HS2ST1 (HGNC:5193) |
|---|---|
| Synonyms | HS2ST, KIAA0448 |
| Function | Catalyzes the transfer of a sulfo group from 3'-phospho-5'- adenylyl sulfate (PAPS) to the 2-OH position of iduronic acid (IdoA) or glucuronic acid (GlcA) within the heparan sulfate (HS) chain and participates in HS biosynthesis (By similarity). Required for metanephric development of kidney formation, suggesting that 2-O- sulfation within HS is essential for signaling between ureteric bud and metanephric mesenchyme (By similarity). |
| Cellular Location | Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8R3H7}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8R3H7} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes heparan sulfate 2-O-sulfotransferase, a member of the heparan sulfate biosynthetic enzyme family. This family member transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation.
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