SLC28A2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q62773 |
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Gene ID | 60423 |
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Other Names | Sodium/nucleoside cotransporter 2, Concentrative nucleoside transporter 2, CNT 2, rCNT2, Na(+)/nucleoside cotransporter 2, Sodium-coupled nucleoside transporter 2, Sodium/purine nucleoside cotransporter, SPNT, Solute carrier family 28 member 2, Slc28a2, Cnt2, Spnt |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7738b was selected from the C-term region of human SLC28A2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | Slc28a2 |
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Synonyms | Cnt2, Spnt {ECO:0000303|PubMed:7775409} |
Function | Sodium-dependent and purine-selective (PubMed:7775409, PubMed:8967974, PubMed:1315767). Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine) (PubMed:7775409, PubMed:8967974, PubMed:1315767). Accepts purine, analogs of purine nucleosides and uridine, and exhibits high affinity for adenosine (PubMed:7775409). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (By similarity). |
Cellular Location | Membrane {ECO:0000250|UniProtKB:O43868}; Multi- pass membrane protein. Apicolateral cell membrane {ECO:0000250|UniProtKB:O43868}; Multi-pass membrane protein |
Tissue Location | Expressed in liver (in bile canalicular membrane vesicles (CMV) but not in sinusoidal vesicles), jejunum, spleen and heart (PubMed:7775409). Also expressed in brain and skeletal muscle (PubMed:7775409). Not expressed in kidney, muscle and lung (PubMed:7775409). |
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Provided below are standard protocols that you may find useful for product applications.
Background
SLC28A2 regulates adenosine transport across the blood-brain barrier into the brain.
References
Li,L., Pharmacogenet. Genomics 17 (9), 783-786 (2007)
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