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CDK5R2(p39) Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q13319 |
|---|---|
| Clone Names | 6010972 |
| Gene ID | 8941 |
|---|---|
| Other Names | Cyclin-dependent kinase 5 activator 2, CDK5 activator 2, Cyclin-dependent kinase 5 regulatory subunit 2, p39, p39I, CDK5R2, NCK5AI |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7742a was selected from the p39 region of human CDK5R2(p39). A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CDK5R2 |
|---|---|
| Synonyms | NCK5AI |
| Function | Activator of CDK5/TPKII. |
| Cellular Location | Cell membrane; Lipid-anchor; Cytoplasmic side |
| Tissue Location | Brain and neuron specific. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CDK5R2(p39) is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins.
References
Rademakers,R., Neurobiol. Aging 26 (8), 1145-1151 (2005)Dhavan,R., J. Neurosci. 22 (18), 7879-7891 (2002)Patzke,H., J. Biol. Chem. 277 (10), 8054-8060 (2002)
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