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MUC20 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession Q8N307
Other Accession Q86ST8
Additional Information
Gene ID 200958
Other Names Mucin-20, MUC-20, MUC20, KIAA1359
Target/Specificity The synthetic peptide sequence is selected from aa 669-684 of HUMAN MUC20
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MUC20
Synonyms KIAA1359
Function May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.
Cellular Location Secreted. Apical cell membrane. Basolateral cell membrane. Cell projection, microvillus membrane
Tissue Location Highly expressed in kidney, moderately in placenta, lung, prostate, liver, and digestive system. In the kidney, localized in the proximal tubules but not in the glomerulus or distal tubules Detected in most of the male urogenital tract epithelia, with the exception of epididymis.
Research Areas
Citations (0)
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Background

This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The shorter isoform expressed by this gene is localized to the plasma membrane, whereas the longer isoform might be secreted. The C terminus of this protein associates with the multifunctional docking site of the met proto-oncogene and suppresses activation of some downstream met signaling cascades. The protein features a tandem repeat domain that varies between 2 and 6 copies in different individuals. Multiple transcript variants encoding different isoforms have been found for this gene.

References

Li,G., Am. J. Nephrol. 26 (1), 43-49 (2006)
Suzuki,Y., Genome Res. 14 (9), 1711-1718 (2004)
Higuchi,T., Mol. Cell. Biol. 24 (17), 7456-7468 (2004)
Higuchi,T., J. Biol. Chem. 279 (3), 1968-1979 (2004)

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$ 277.78
Cat# BP7830b
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