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MEKK3 Blocking Peptide (N-term E29)

Synthetic peptide

     
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Product Information
Primary Accession Q99759
Additional Information
Gene ID 4215
Other Names Mitogen-activated protein kinase kinase kinase 3, MAPK/ERK kinase kinase 3, MEK kinase 3, MEKK 3, MAP3K3, MAPKKK3, MEKK3
Target/Specificity The synthetic peptide sequence is selected from aa 29-44 of HUMAN MAP3K3
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP3K3
Synonyms MAPKKK3, MEKK3
Function Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.
Research Areas
Citations (0)
citation

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Background

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK3 preferentially activates p42/44 (ERK2/ERK1) MAP kinases.

References

Ellinger-Ziegelbauer H.C.,J. Biol. Chem. 272:2668-2674(1997).
Nakamura K.,J. Biol. Chem. 278:36989-36992(2003).
Huang Q.,Nat. Immunol. 5:98-103(2004).
Bouwmeester T.,Nat. Cell Biol. 6:97-105(2004).

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$ 277.78
Cat# BP7909d
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