HK3 (Hexokinase III) Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P52790 |
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Other Accession | NP_002106 |
Gene ID | 3101 |
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Other Names | Hexokinase-3, Hexokinase type III, HK III, HK3 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8139e was selected from the C-term region of human HK3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | HK3 (HGNC:4925) |
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Function | Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively) (PubMed:8717435). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:8717435). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate.
References
Sui, D., et al., Arch. Biochem. Biophys. 382(2):262-274 (2000).Lowes, W., et al., Biochim. Biophys. Acta 1379(1):134-142 (1998).Furuta, H., et al., Genomics 36(1):206-209 (1996).Palma, F., et al., Mol. Cell. Biochem. 155(1):23-29 (1996).Colosimo, A., et al., Cytogenet. Cell Genet. 74(3):187-188 (1996).
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