|Other Names||Cysteine and histidine-rich domain-containing protein 1, CHORD domain-containing protein 1, CHORD-containing protein 1, CHP-1, Protein morgana, CHORDC1, CHP1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8606c was selected from the Center region of human CHORDC1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis.|
|Tissue Location||Underexpressed in many breast and lung cancers.|
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Provided below are standard protocols that you may find useful for product applications.
CHORDC1 may be play a role in the regulation of NOD1 via its interaction with HSP90AA1.
Shirasu,K., et.al., Cell 99 (4), 355-366 (1999)
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