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CHORDC1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UHD1 |
|---|---|
| Clone Names | 90909168 |
| Gene ID | 26973 |
|---|---|
| Other Names | Cysteine and histidine-rich domain-containing protein 1, CHORD domain-containing protein 1, CHORD-containing protein 1, CHP-1, Protein morgana, CHORDC1, CHP1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8606c was selected from the Center region of human CHORDC1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CHORDC1 |
|---|---|
| Synonyms | CHP1 |
| Function | Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 (PubMed:20230755). Proposed to act as co- chaperone for HSP90 (PubMed:20230755). May play a role in the regulation of NOD1 via a HSP90 chaperone complex (PubMed:20230755). In vitro, has intrinsic chaperone activity (PubMed:20230755). This function may be achieved by inhibiting association of ROCK2 with NPM1 (PubMed:20230755). Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (PubMed:32053105). Involved in stress response (PubMed:20230755). Prevents tumorigenesis (PubMed:20230755). |
| Tissue Location | Underexpressed in many breast and lung cancers. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CHORDC1 may be play a role in the regulation of NOD1 via its interaction with HSP90AA1.
References
Shirasu,K., et.al., Cell 99 (4), 355-366 (1999)
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