|Other Names||DNA-directed RNA polymerase I subunit RPA34, A345, Antisense to ERCC-1 protein, ASE-1, CD3-epsilon-associated protein, CAST, CD3E-associated protein, RNA polymerase I-associated factor PAF49, CD3EAP, ASE1, CAST, PAF49|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8607a was selected from the N-term region of human CD3EAP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF-activated transcription, presumably at a step following PIC formation.|
|Cellular Location||Nucleus, nucleolus. Chromosome. Note=Found at the fibrillar centers of the nucleolus in interphase and during cell division it is localized to the nucleolus organizer regions of the chromosomes|
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Provided below are standard protocols that you may find useful for product applications.
CD3EAP is a DNA dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. It is a component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF activated transcription, presumably at a step following PIC formation.
Yamazaki,T., et.al., J. Biol. Chem. 274 (26), 18173-18180 (1999)Whitehead,C.M., et.al., Chromosoma 106 (8), 493-502 (1997)
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