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MUT Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P22033 |
|---|---|
| Clone Names | 90625013 |
| Gene ID | 4594 |
|---|---|
| Other Names | Methylmalonyl-CoA mutase, mitochondrial, MCM, Methylmalonyl-CoA isomerase, MUT |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8663c was selected from the Center region of human MUT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MMUT (HGNC:7526) |
|---|---|
| Function | Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle. |
| Cellular Location | Mitochondrion matrix. Mitochondrion. Cytoplasm |
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Provided below are standard protocols that you may find useful for product applications.
Background
MUT is the mitochondrial enzyme methylmalonyl Coenzyme A mutase. In humans, the protein is a vitamin B12-dependent enzyme which catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA, while in other species this enzyme may have different functions.
References
Crane,A.M., et.al., Hum. Genet. 89 (3), 259-264 (1992)Crane,A.M., et.al., J. Clin. Invest. 89 (2), 385-391 (1992)
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