|Other Names||Methylmalonyl-CoA mutase, mitochondrial, MCM, Methylmalonyl-CoA isomerase, MUT|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8663c was selected from the Center region of human MUT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species.|
|Cellular Location||Mitochondrion matrix.|
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Provided below are standard protocols that you may find useful for product applications.
MUT is the mitochondrial enzyme methylmalonyl Coenzyme A mutase. In humans, the protein is a vitamin B12-dependent enzyme which catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA, while in other species this enzyme may have different functions.
Crane,A.M., et.al., Hum. Genet. 89 (3), 259-264 (1992)Crane,A.M., et.al., J. Clin. Invest. 89 (2), 385-391 (1992)
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