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ALDH3B1 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P43353
Clone Names 90819091
Additional Information
Gene ID 221
Other Names Aldehyde dehydrogenase family 3 member B1, Aldehyde dehydrogenase 7, ALDH3B1, ALDH7
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8706c was selected from the Center region of human ALDH3B1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ALDH3B1
Synonyms ALDH7
Function Oxidizes medium and long chain saturated and unsaturated fatty aldehydes generated in the plasma membrane into non-toxic fatty acids (PubMed:17382292, PubMed:23721920). May have a protective role against the cytotoxicity induced by lipid peroxidation (PubMed:17382292). Short-chain fatty aldehydes are not good substrates (PubMed:17382292). Can use both NADP(+) and NAD(+) as electron acceptor in vitro, however in vivo preference will depend on their tissue levels (PubMed:17382292). Low activity towards acetaldehyde and 3,4- dihydroxyphenylacetaldehyde (PubMed:17382292, PubMed:23721920). Able to metabolize aromatic aldehydes such as benzaldehyde to their acid form (PubMed:17382292).
Cellular Location Cell membrane; Lipid-anchor. Note=Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm
Tissue Location Highest expression in kidney and lung.
Research Areas
Citations (0)
citation

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Background

The aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation.

References

Marchitti,S.A., et.al., Biochem. Biophys. Res. Commun. 356 (3), 792-798 (2007)

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$ 277.78
Cat# BP8706c
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Availability: 2 weeks
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