DIO2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q92813 |
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Clone Names | 90723035 |
Gene ID | 1734 |
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Other Names | Type II iodothyronine deiodinase, 5DII, DIOII, Type 2 DI, Type-II 5'-deiodinase, DIO2, ITDI2, TXDI2 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8718c was selected from the Center region of human DIO2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DIO2 |
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Synonyms | ITDI2, TXDI2 |
Function | Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. |
Cellular Location | Membrane; Single-pass membrane protein |
Tissue Location | Isoform 1 is expressed in the lung, trachea, kidney, heart, skeletal muscle, placenta, fetal brain and several regions of the adult brain (PubMed:8755651, PubMed:11165050). Isoform 2 is expressed in the brain, heart, kidney and trachea (PubMed:11165050) |
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Provided below are standard protocols that you may find useful for product applications.
Background
DIO2 belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3).
References
He,B.,et.al., Prog. Neuropsychopharmacol. Biol. Psychiatry 33 (6), 986-990 (2009)Heemstra,K.A., et.al., J. Clin. Endocrinol. Metab. 94 (6), 2144-2150 (2009)
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