|Other Names||Toll/interleukin-1 receptor domain-containing adapter protein, TIR domain-containing adapter protein, Adaptor protein Wyatt, MyD88 adapter-like protein, MyD88-2, TIRAP, MAL|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8759b was selected from the C-term region of human TIRAP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.|
|Cellular Location||Cytoplasm. Cell membrane. Membrane. Note=Colocalizes with DAB2IP at the plasma membrane|
|Tissue Location||Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain|
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Provided below are standard protocols that you may find useful for product applications.
Adapter involved in the TLR4 signaling pathway in the innate immune response. TIRAP acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, resulting in cytokine secretion and the inflammatory response.
Eto,A., et.al., Biochem. Biophys. Res. Commun. 301 (2), 495-501 (2003)
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