|Other Names||Disintegrin and metalloproteinase domain-containing protein 30, ADAM 30, 3424-, ADAM30|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8805b was selected from the C-term region of human ADAM30. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation (PubMed:27333034).|
|Cellular Location||Late endosome membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in brain neurons (at protein level) (PubMed:27333034). Expressed in testis (PubMed:10512762)|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
ADAM30 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis.
Hu,C., et.al., PLoS ONE 4 (10), E7643 (2009)
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