ADAM30 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UKF2 |
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Clone Names | 90723003 |
Gene ID | 11085 |
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Other Names | Disintegrin and metalloproteinase domain-containing protein 30, ADAM 30, 3424-, ADAM30 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8805b was selected from the C-term region of human ADAM30. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ADAM30 |
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Function | Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation (PubMed:27333034). |
Cellular Location | Late endosome membrane; Single-pass type I membrane protein |
Tissue Location | Expressed in brain neurons (at protein level) (PubMed:27333034). Expressed in testis (PubMed:10512762) |
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Provided below are standard protocols that you may find useful for product applications.
Background
ADAM30 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis.
References
Hu,C., et.al., PLoS ONE 4 (10), E7643 (2009)
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