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ABHD12 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8N2K0
Clone Names 90819019
Additional Information
Gene ID 26090
Other Names Monoacylglycerol lipase ABHD12, 2-arachidonoylglycerol hydrolase, Abhydrolase domain-containing protein 12, ABHD12, C20orf22
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8904a was selected from the N-term region of human ABHD12. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ABHD12 {ECO:0000303|PubMed:20797687, ECO:0000312|HGNC:HGNC:15868}
Function Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (PubMed:25290914, PubMed:30237167, PubMed:30420694, PubMed:30720278, PubMed:30643283). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal (PubMed:30643283). Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways (PubMed:22969151, PubMed:24027063). Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (PubMed:30237167).
Cellular Location Endoplasmic reticulum membrane; Single-pass membrane protein
Research Areas
Citations (0)

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Background

ABHD12 has 2-arachidonoylglycerol hydrolase activity (By similarity). It may be a regulator of endocannabinoid signaling pathways (By similarity).

References

Bechtel S., et.al., BMC Genomics 8:399-399(2007).

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$ 277.78
Cat# BP8904a
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Availability: 2 weeks
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