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ADRBK2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P35626 |
|---|---|
| Clone Names | 90429010 |
| Gene ID | 157 |
|---|---|
| Other Names | Beta-adrenergic receptor kinase 2, Beta-ARK-2, G-protein-coupled receptor kinase 3, ADRBK2, BARK2, GRK3 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP9092a was selected from the N-term region of human ADRBK2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GRK3 (HGNC:290) |
|---|---|
| Function | Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors. |
| Cellular Location | Postsynapse {ECO:0000250|UniProtKB:P26819}. Presynapse {ECO:0000250|UniProtKB:P26819} |
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Provided below are standard protocols that you may find useful for product applications.
Background
ADRBK2 is the beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
References
Gratacos,M., et.al., Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009)Rao,J.S., et.al., Int. J. Neuropsychopharmacol. 12 (6), 851-860 (2009)
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