|Other Names||Protein-lysine 6-oxidase, Lysyl oxidase, LOX|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9127c was selected from the Center region of human LOX. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity).|
|Cellular Location||Secreted. Secreted, extracellular space|
|Tissue Location||Heart, placenta, skeletal muscle, kidney, lung and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
LOX is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression.
Mariani,T.J., et.al., Matrix 12 (3), 242-248 (1992)
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