SELS Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9BQE4 |
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Clone Names | 90909103 |
Gene ID | 55829 |
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Other Names | Selenoprotein S, SelS, VCP-interacting membrane protein, VIMP, SELS |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP9171c was selected from the Center region of human SELS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SELENOS {ECO:0000303|PubMed:27645994, ECO:0000312|HGNC:HGNC:30396} |
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Function | Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination. |
Cellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein. Cytoplasm |
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Provided below are standard protocols that you may find useful for product applications.
Background
Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.
References
McGeachie,M., et.al., Circulation 120 (24), 2448-2454 (2009)Kelly,E., et.al., J. Biol. Chem. 284 (25), 16891-16897 (2009)
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