|Other Names||Parathyroid hormone 2 receptor, PTH2 receptor, PTH2R, PTHR2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9263c was selected from the Center region of human PTH2R. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed abundantly in brain and pancreas. Also expressed in the testis.|
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Provided below are standard protocols that you may find useful for product applications.
The protein is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas.
Bago,A.G., et.al, Neuroscience 162 (1), 128-147 (2009)Mann,R., et.al, Mol. Pharmacol. 74 (3), 605-613 (2008)Tenne,M., et.al, Bone 42 (4), 719-727 (2008)
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