|Other Names||Heparan sulfate glucosamine 3-O-sulfotransferase 3A1, Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1, 3-OST-3A, Heparan sulfate 3-O-sulfotransferase 3A1, h3-OST-3A, HS3ST3A1, 3OST3A1, HS3ST3A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.|
|Cellular Location||Golgi apparatus membrane; Single- pass type II membrane protein|
|Tissue Location||Ubiquitous. Most abundant in heart and placenta, followed by liver and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. The sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1, and these two enzymes sulfate an identical disaccharide.
Levy, D., et al. BMC Med. Genet. 8 SUPPL 1, S3 (2007) : Moon, A.F., et al. J. Biol. Chem. 279(43):45185-45193(2004) Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003) Salehi, L.B., et al. Hum. Genet. 111 (4-5), 401-404 (2002) : Liu, J., et al. J. Biol. Chem. 274(53):38155-38162(1999) Shukla, D., et al. Cell 99(1):13-22(1999)
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