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ADD1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P35611 |
|---|
| Gene ID | 118 |
|---|---|
| Other Names | Alpha-adducin, Erythrocyte adducin subunit alpha, ADD1, ADDA |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ADD1 |
|---|---|
| Synonyms | ADDA |
| Function | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. |
| Cellular Location | Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side |
| Tissue Location | Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C.
References
Davila, S., et al. Genes Immun. (2010) In press : Paternoster, L., et al. Circ Cardiovasc Genet 3(1):15-21(2010) Ferrandi, M., et al. J. Mol. Med. 88(2):203-217(2010) Wang, R., et al. J. Appl. Genet. 51(1):87-94(2010) Niu, W.Q., et al. J Hum Hypertens (2009) In press : Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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