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IK Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q13123
Additional Information
Gene ID 3550
Other Names Protein Red, Cytokine IK, IK factor, Protein RER, IK, RED, RER
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name IK
Synonyms RED {ECO:0000303|PubMed:10216252}, RER
Function Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:28781166). Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression (PubMed:22351768, PubMed:24252166). Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint (PubMed:22351768). Required for normal accumulation of SMU1 (PubMed:24945353).
Cellular Location Nucleus. Nucleus, nucleoplasm. Chromosome. Cytoplasm, cytoskeleton, spindle pole. Note=Predominantly present throughout the nucleoplasm during prometaphase, metaphase and anaphase. Is also detected in nuclear foci that are not identical with Cajal bodies Starts to accumulate at chromosomes during telophase, and is nearly exclusively associated with chromosomes in newly divided cells (PubMed:24252166). Colocalizes with MAD1L1 at mitotic spindle poles during metaphase and anaphase (PubMed:22351768)
Tissue Location Ubiquitous..
Research Areas
Citations (0)

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Background

IK was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown.

References

Davila, S., et al. Genes Immun. (2010) In press :Koskinen, L.L., et al. Tissue Antigens 74(5):408-416(2009)Friedrichs, F., et al. Genome Res. 19(3):395-403(2009)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Stelzl, U., et al. Cell 122(6):957-968(2005)

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$ 277.78
Cat# BP9536c
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