|Other Names||Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial, 3-oxoacid CoA-transferase 1, Somatic-type succinyl-CoA:3-oxoacid CoA-transferase, SCOT-s, OXCT1, OXCT, SCOT|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.|
|Cellular Location||Mitochondrion matrix.|
|Tissue Location||Abundant in heart, followed in order by kidney, brain, and muscle, whereas in liver it is undetectable; also detectable in leukocytes and fibroblasts|
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Provided below are standard protocols that you may find useful for product applications.
OXCT1 is a member of the 3-oxoacid CoA-transferase gene family. This protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate.
??artins-de-Souza, D., et al. J Psychiatr Res (2010) In press :??acDonald, M.J., et al. Diabetologia 52(6):1087-1091(2009)??rii, K.E., et al. Tohoku J. Exp. Med. 215(3):227-236(2008)??ukao, T., et al. Mol. Genet. Metab. 92(3):216-221(2007)??ukao, T., et al. Mol. Genet. Metab. 89(3):280-282(2006)
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