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AQP10 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q96PS8
Additional Information
Gene ID 89872
Other Names Aquaporin-10, AQP-10, Aquaglyceroporin-10, Small intestine aquaporin, AQP10
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name AQP10
Function [Isoform 1]: Water channel that mediates water transport across cell membranes irrespective of the cytosolic pH (PubMed:12084581, PubMed:21733844, PubMed:23382902, PubMed:30420639). The channel is permeable to glycerol, especially when the cytosolic pH is acidified (PubMed:21733844, PubMed:30420639). Contributes to adipocyte water and glycerol permeability, and may thereby contribute to the utilization of glycerol derived from phospholipid degradation (PubMed:23382902). May contribute to water transport in the intestine (Probable).
Cellular Location Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Lipid droplet. Note=Detected around lipid droplets
Tissue Location Detected in epithelial cells on villi in the ileum, and also in stomach, jejunum, colon, rectum, white adipose tissue and placenta (at protein level) (PubMed:15221416, PubMed:23382902) Expressed in duodenum and jejunum. Highest expression in absorptive epithelial cells at the tips of villi in the jejunum (PubMed:11573934, PubMed:12084581). Detected in subcutaneous adipose tissue (PubMed:23382902).
Research Areas
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Background

AQP10 is a member of the aquaglyceroporin family of integral membrane proteins. Members of this family function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and urea.

References

??hapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)??uke, M.M., et al. Stroke 40(2):363-368(2009)??ohly, H.H., et al. Int J Environ Res Public Health 5(2):115-119(2008)??hiffman, D., et al. Arterioscler. Thromb. Vasc. Biol. 28(1):173-179(2008)??lach, C.F., et al. FEBS Lett. 581(17):3183-3188(2007)

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$ 277.78
Cat# BP9576b
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