|Other Names||Aquaporin-10, AQP-10, Aquaglyceroporin-10, Small intestine aquaporin, AQP10|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||[Isoform 1]: Water channel that mediates water transport across cell membranes irrespective of the cytosolic pH (PubMed:12084581, PubMed:21733844, PubMed:23382902, PubMed:30420639). The channel is permeable to glycerol, especially when the cytosolic pH is acidified (PubMed:21733844, PubMed:30420639). Contributes to adipocyte water and glycerol permeability, and may thereby contribute to the utilization of glycerol derived from phospholipid degradation (PubMed:23382902). May contribute to water transport in the intestine (Probable).|
|Cellular Location||Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Lipid droplet. Note=Detected around lipid droplets|
|Tissue Location||Detected in epithelial cells on villi in the ileum, and also in stomach, jejunum, colon, rectum, white adipose tissue and placenta (at protein level) (PubMed:15221416, PubMed:23382902) Expressed in duodenum and jejunum. Highest expression in absorptive epithelial cells at the tips of villi in the jejunum (PubMed:11573934, PubMed:12084581). Detected in subcutaneous adipose tissue (PubMed:23382902).|
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Provided below are standard protocols that you may find useful for product applications.
AQP10 is a member of the aquaglyceroporin family of integral membrane proteins. Members of this family function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and urea.
??hapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)??uke, M.M., et al. Stroke 40(2):363-368(2009)??ohly, H.H., et al. Int J Environ Res Public Health 5(2):115-119(2008)??hiffman, D., et al. Arterioscler. Thromb. Vasc. Biol. 28(1):173-179(2008)??lach, C.F., et al. FEBS Lett. 581(17):3183-3188(2007)
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