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FAM175A Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6UWZ7 |
|---|
| Gene ID | 84142 |
|---|---|
| Other Names | BRCA1-A complex subunit Abraxas, Coiled-coil domain-containing protein 98, Protein FAM175A, FAM175A, ABRA1, CCDC98 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ABRAXAS1 (HGNC:25829) |
|---|---|
| Function | Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. |
| Cellular Location | Nucleus Note=Localizes at sites of DNA damage at double-strand breaks (DSBs) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.
References
Wang, B., et al. Genes Dev. 23(6):729-739(2009)Feng, L., et al. Genes Dev. 23(6):719-728(2009)Shao, G., et al. Genes Dev. 23(6):740-754(2009)
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