HFE2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q6ZVN8 |
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Gene ID | 148738 |
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Other Names | Hemojuvelin, Hemochromatosis type 2 protein, RGM domain family member C, HFE2, HJV, RGMC |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | HJV (HGNC:4887) |
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Synonyms | HFE2, RGMC |
Function | Acts as a bone morphogenetic protein (BMP) coreceptor (PubMed:18976966). Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis (PubMed:18976966). |
Cellular Location | Cell membrane; Lipid-anchor, GPI- anchor. Note=Also released in the extracellular space |
Tissue Location | Adult and fetal liver, heart, and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin.
References
Zhu, X., et al. Genet. Epidemiol. 34(2):171-187(2010)Barton, J.C., et al. Am. J. Hematol. 84(11):710-714(2009)Zhang, A.S., et al. J. Biol. Chem. 284(34):22580-22589(2009)
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