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NCR3 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O14931 |
|---|
| Gene ID | 259197 |
|---|---|
| Other Names | Natural cytotoxicity triggering receptor 3, Activating natural killer receptor p30, Natural killer cell p30-related protein, NK-p30, NKp30, CD337, NCR3, 1C7, LY117 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NCR3 |
|---|---|
| Synonyms | 1C7, LY117 |
| Function | Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Selectively expressed by all resting and activated NK cells and weakly expressed in spleen. {ECO:0000269|PubMed:10562324, ECO:0000269|Ref.2} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Natural cytotoxicity receptors (NCRs), such as NCR3, are activating natural killer (NK) cell receptors that belong to the immunoglobulin (Ig) superfamily. NCR3 is expressed in all resting and activated NK cells and forms a complex with CD3-zeta.
References
Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) Balsamo, M., et al. Exp. Hematol. 37(10):1167-1175(2009)Hoechst, B., et al. Hepatology 50(3):799-807(2009)Brandt, C.S., et al. J. Exp. Med. 206(7):1495-1503(2009)Djeu, J.Y., et al. Clin. Cancer Res. 8(3):636-640(2002)Sato, M., et al. Tissue Antigens 58(4):255-258(2001)Sivakamasundari, R., et al. Immunogenetics 51 (8-9), 723-732 (2000)
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