KLC2 Antibody (C-Term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9H0B6 |
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Other Accession | NP_073733 |
Gene ID | 64837 |
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Other Names | Kinesin light chain 2, KLC 2, KLC2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | KLC2 (HGNC:20716) |
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Function | Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends (PubMed:22172677). |
Cellular Location | Cytoplasm, cytoskeleton. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side |
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Provided below are standard protocols that you may find useful for product applications.
Background
Kinesin is a molecular motor that generates ATP-dependent movement of vesicles and organelles along microtubules. Kinesin consists of 2 light chains, such as KLC2, and 2 heavy chains (see KIF5B; MIM 602809) in a 1:1 stoichiometric ratio.
References
Trejo, H.E., et al. FASEB J. 24(2):374-382(2010)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Olsen, J.V., et al. Cell 127(3):635-648(2006)Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)Lim, J., et al. Cell 125(4):801-814(2006)
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