BSND Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8WZ55 |
---|
Gene ID | 7809 |
---|---|
Other Names | Barttin, BSND, BART |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | BSND |
---|---|
Synonyms | BART |
Function | Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter. |
Cellular Location | Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=A significant amount also observed intracellularly. Staining in membranes of the renal tubule and of potassium-secreting epithelia of the inner ear is basolateral (By similarity). |
Tissue Location | Expressed primarily in kidney. Expressed in specific nephron segments and in the stria vascularis of the inner ear |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
BSND encodes an essential beta subunit for CLC chloride channels. These heteromeric channels localize to basolateral membranes of renal tubules and of potassium-secreting epithelia of the inner ear.
References
Riazuddin, S., et al. Am. J. Hum. Genet. 85(2):273-280(2009)Brochard, K., et al. Nephrol. Dial. Transplant. 24(5):1455-1464(2009)Bircan, Z., et al. Pediatr. Nephrol. 24(4):841-844(2009)Kathiresan, S., et al. Nat. Genet. 41(3):334-341(2009)Kathiresan, S., et al. Nat. Genet. 41(1):56-65(2009)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.