DCLRE1A Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q6PJP8 |
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Gene ID | 9937 |
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Other Names | DNA cross-link repair 1A protein, SNM1 homolog A, hSNM1, hSNM1A, DCLRE1A, KIAA0086, SNM1, SNM1A |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DCLRE1A |
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Synonyms | KIAA0086, SNM1, SNM1A |
Function | May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (PubMed:31434986). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (PubMed:31434986). |
Cellular Location | Nucleus. Note=In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross-linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11, RAD50 and NBN) and BRCA1 |
Tissue Location | Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1A is one of several evolutionarily conserved genes involved in repair of interstrand cross-links.
References
Akhter, S., et al. Biochem. Biophys. Res. Commun. 377(1):236-241(2008)Hemphill, A.W., et al. Mol. Genet. Metab. 94(1):38-45(2008)Hazrati, A., et al. DNA Repair (Amst.) 7(2):230-238(2008)Hejna, J., et al. Nucleic Acids Res. 35(18):6115-6123(2007)
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