SCIN Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y6U3 |
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Gene ID | 85477 |
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Other Names | Adseverin, Scinderin, SCIN, KIAA1905 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SCIN {ECO:0000303|PubMed:8547642, ECO:0000312|HGNC:HGNC:21695} |
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Function | Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:8547642, PubMed:26365202). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009). |
Cellular Location | Cytoplasm, cytoskeleton. Cell projection, podosome {ECO:0000250|UniProtKB:Q60604} |
Tissue Location | Expressed in megakaryocytes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SCIN (Scinderin) is a Ca(2+) dependent actin filament severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro SCIN also has barbed end capping and nucleating activities in the presence of Ca(2+).
References
Chumnarnsilpa, S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(33):13719-13724(2009)Ehre, C., et al. Am. J. Physiol., Cell Physiol. 288 (1), C46-C56 (2005) Lejen, T., et al. Ann. N. Y. Acad. Sci. 971, 248-250 (2002)
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