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IL-1 beta, rat recombinant protein
Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediato
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q63264 |
|---|---|
| Calculated MW | 17.3 kDa |
| Gene ID | UniGene:Rn.9869 |
|---|---|
| Gene Symbol | IL1B |
| Other Names | Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF) |
| Gene Source | Rat |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥98% |
| Assay2&Purity2 | HPLC; ≥98% |
| Recombinant | Yes |
| Results | <0.1 ng/ml, |
| Target/Specificity | IL-1 beta |
| Application Notes | Centrifuge the vial prior to opening. Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and stored at +4°C for 1 week or –20°C for future use. |
| Format | Lyophilized protein |
| Storage | -20°C; Sterile filtered and then lyophilized from 10 mM Sodium Acetate, pH 6.5 |
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Provided below are standard protocols that you may find useful for product applications.
Background
IL-1β is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, B-cell maturation and proliferation, mitogenic FGF-like activity and stimulation of the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant rat IL-1β is a 17.4 kDa protein containing 153 amino acid residues.
References
Feeser W.,et al.Submitted (AUG-1992) to the EMBL/GenBank/DDBJ databases.
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