Cathepsin K Blocking Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O35186 |
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Other Accession | NP_113748 |
Gene ID | 29175 |
Calculated MW | 36791 Da |
Gene ID | 29175 |
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Application & Usage | The peptide is used for blocking the antibody activity of cathepsin K. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 1 hour at 37°C. |
Other Names | Cathepsin K, 3.4.22.38, Ctsk |
Target/Specificity | Cathepsin K |
Formulation | 50 µg (0.2 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 0.1% BSA and 0.02% thimerosal. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | Cathepsin K Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Ctsk |
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Function | Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. |
Cellular Location | Lysosome {ECO:0000250|UniProtKB:P43235}. Secreted {ECO:0000250|UniProtKB:P43235}. Apical cell membrane {ECO:0000250|UniProtKB:P43235}; Peripheral membrane protein {ECO:0000250|UniProtKB:P43235}; Extracellular side {ECO:0000250|UniProtKB:P43235}. Note=Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells {ECO:0000250|UniProtKB:P43235} |
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