Myostatin Proform, human recombinant protein
GDF-8, MSTN, Growth Differentiation Factor 8, MSTN Muscle Hypertrophy,
|Calculated MW||27.8 kDa|
|Other Names||GDF-8, MSTN, Growth Differentiation Factor 8, MSTN Muscle Hypertrophy,|
|Application Notes||Reconstitute in H₂O to a concentration of 0.1 to 1.0 mg/ml. This solution can then be diluted into other aqueous buffers|
|Storage||-20°C; Sterile filtered and lyophilized with no additives|
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Provided below are standard protocols that you may find useful for product applications.
Mature Myostatin is obtained by proteolytic processing of a biologically-inactive precursor protein, which contains an N-terminal propeptide of 243 amino acid residues. Myostatin Propeptide exhibits high binding affinity for myostatin and has been shown to be a potent inhibitor of Myostatin. Over-expression of myostatin propeptide in mice resulted in large increases (up to 200%) in skeletal muscle mass, similar to those observed in Myostatin knockout mice. Recombinant Human Myostatin Propeptide is a 27.8 kDa protein consisting of 244 amino acid residues
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Gonzalez-Cadavid N.F.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:14938-14943(1998).
Saunders M.A.,et al.Am. J. Hum. Genet. 79:1089-1097(2006).
Hill J.J.,et al.Mol. Endocrinol. 17:1144-1154(2003).
Schuelke M.,et al.N. Engl. J. Med. 350:2682-2688(2004).
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