Myostatin Proform, human recombinant protein
GDF-8, MSTN, Growth Differentiation Factor 8, MSTN Muscle Hypertrophy,
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O14793 |
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Calculated MW | 27.8 kDa |
Gene ID | 2660 |
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Gene Symbol | MSTN |
Other Names | GDF-8, MSTN, Growth Differentiation Factor 8, MSTN Muscle Hypertrophy, |
Gene Source | Human |
Source | E. coli |
Assay&Purity | SDS-PAGE; ≥98% |
Assay2&Purity2 | HPLC; ≥98% |
Recombinant | Yes |
Target/Specificity | Myostatin |
Application Notes | Reconstitute in H₂O to a concentration of 0.1 to 1.0 mg/ml. This solution can then be diluted into other aqueous buffers |
Format | Lyophilized protein |
Storage | -20°C; Sterile filtered and lyophilized with no additives |
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Provided below are standard protocols that you may find useful for product applications.
Background
Mature Myostatin is obtained by proteolytic processing of a biologically-inactive precursor protein, which contains an N-terminal propeptide of 243 amino acid residues. Myostatin Propeptide exhibits high binding affinity for myostatin and has been shown to be a potent inhibitor of Myostatin. Over-expression of myostatin propeptide in mice resulted in large increases (up to 200%) in skeletal muscle mass, similar to those observed in Myostatin knockout mice. Recombinant Human Myostatin Propeptide is a 27.8 kDa protein consisting of 244 amino acid residues
References
McPherron A.C.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:12457-12461(1997).
Gonzalez-Cadavid N.F.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:14938-14943(1998).
Saunders M.A.,et al.Am. J. Hum. Genet. 79:1089-1097(2006).
Hill J.J.,et al.Mol. Endocrinol. 17:1144-1154(2003).
Schuelke M.,et al.N. Engl. J. Med. 350:2682-2688(2004).
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