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PTHrP, human recombinant protein
PTH/PTHrP receptor antagonist, PTHrP analog, PTHR, MGC138426, MGC138452
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P12272 |
|---|---|
| Calculated MW | 9.8 kDa |
| Gene ID | 5744 |
|---|---|
| Gene Symbol | PTHLH |
| Other Names | PTH/PTHrP receptor antagonist, PTHrP analog, PTHR, MGC138426, MGC138452 |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥98% |
| Assay2&Purity2 | HPLC; ≥98% |
| Recombinant | Yes |
| Target/Specificity | PTHrP |
| Application Notes | Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers |
| Format | Lyophilized protein |
| Storage | -20°C; Sterile filtered and lyophilized with no additives |
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Provided below are standard protocols that you may find useful for product applications.
Background
Parathyroid Hormone-like related Protein (PTHrP) is a member of the Parathyroid hormone family that is expressed in the mammary gland. It is known as a potent inhibitor of chondrocyte maturation. PTHrP is expressed by periarticular perichondrial cells and exerts its biological activity on PP-R expressing cells. During endochondral bone development PTHrP plays a major role in suppressing the onset of hypertrophic differentiation. It is also responsible for most cases of humoral hypercalcemia of malignancy. Recombinant Human PTHrP is a 9.8 kDa protein consisting of 86 amino acid residues.
References
Suva L.J.,et al.Science 237:893-896(1987).
Mangin M.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:597-601(1988).
Yasuda T.,et al.J. Biol. Chem. 264:7720-7725(1989).
Thiede M.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:4605-4609(1988).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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