BMP-14/GDF-5, human recombinant protein
Cartilage-derived morphogenetic protein-1, Cartilage-Derived Morphogenetic Protein-1, CDMP-1, LAP4,
|Calculated MW||26.8 kDa|
|Other Names||Cartilage-derived morphogenetic protein-1, Cartilage-Derived Morphogenetic Protein-1, CDMP-1, LAP4, SYNS2, Radotermin, CDMP1, GDF5, Growth differentiation factor 5, BMP-14|
|Application Notes||Reconstitute in 20 Mm HOAc to a concentration of 0.1 to 1.0 mg/ml. This solution can then be diluted into other aqueous buffers|
|Storage||-20°C; Sterile filtered and lyophilized with no additives|
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Provided below are standard protocols that you may find useful for product applications.
GDF-5 acts as an inhibitor of nerve tissue growth. It is produced as a homodimer, non-glycosylated polypeptide chain containing 2 X 117 amino acids with a molecular weight of 26.8 kDa. To enable bacterial expression of rhGDF-5 we removed the N-terminal sequence Ala-Pro- Leu- Thr and added the Lys.
Hoetten G.,et al.Biochem. Biophys. Res. Commun. 204:646-652(1994).
Chang S.,et al.J. Biol. Chem. 269:28227-28234(1994).
Deloukas P.,et al.Nature 414:865-871(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Triantafilou K.,et al.Nat. Immunol. 2:338-345(2001).
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