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Galectin-3, human recombinant protein
IgE-binding protein, MAC2, L-29, CPB-35
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P17931 |
|---|---|
| Calculated MW | 26.0 kDa |
| Gene ID | 3958 |
|---|---|
| Gene Symbol | LEG3 |
| Other Names | IgE-binding protein, MAC2, L-29, CPB-35, 35 kDa lectin, Carbohydrate-binding protein 35, Galactose-specific lectin 3, Galactoside-binding protein, IgE-binding protein, L-31, Laminin-binding protein, Lectin L-29, Mac-2 antigen |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥98% |
| Assay2&Purity2 | HPLC; |
| Recombinant | Yes |
| Results | 250 µg/ml |
| Application Notes | Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use. |
| Format | Lyophilized protein |
| Storage | -20°C; Sterile filtered and lyophilized from 0.5X PBS, pH 7.2. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Lectins are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with β-galactoside moieties. Galactin-3 regulates a number of biological processes, including embryogenesis, inflammatory responses, cell progression and metastasis. Galectin-3 can function intraCellularly in controlling cell cycle and preventing T-cell apoptosis, and also extraCellularly, in activating various cells, including monocytes/macrophages, mast cells, neutrophils, and lymphocytes. Recombinant Galectin-3 is a globular 26.0 kDa protein containing 250 amino acid residues, but no disulfide bonds.
References
Robertson M.W.,et al.Biochemistry 29:8093-8100(1990).
Cherayil B.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:7324-7328(1990).
Oda Y.,et al.Gene 99:279-283(1991).
Raz A.,et al.Cancer Res. 51:2173-2178(1991).
Lotz M.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:3466-3470(1993).
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