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Elastase, Human Neutrophil recombinant protein
Leukocyte Elastase, ELA2
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P08246 |
|---|---|
| Calculated MW | 29.5 kDa |
| Gene ID | 1991 |
|---|---|
| Gene Symbol | ELANE |
| Other Names | Leukocyte Elastase, ELA2 |
| Source | Human Neutrophil |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | HPLC; |
| Recombinant | No |
| Application Notes | Deionized H₂O |
| Format | Lyophilized protein |
| Storage | -20°C; Salt- free lyophilized solid |
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Provided below are standard protocols that you may find useful for product applications.
Background
Elastase, like trypsin and chymotrypsin, is a serine protease that also hydrolyses amides and esters. It is produced in the pancreas as an inactive zymogen, proelastase, and activated in the duodenum by trypsin. Elastase is distinctive in that it acts upon elastin.This enzyme degrades elastin, collagen, and proteoglycan and has been implicated in the development of pulmonary emphesema and rheumatoid arthritis.
References
Nakamura H.,et al.Nucleic Acids Res. 15:9601-9601(1987).
Takahashi H.,et al.J. Biol. Chem. 263:14739-14747(1988).
Farley D.,et al.Biol. Chem. Hoppe-Seyler 370:737-744(1989).
Okano K.,et al.Biochem. Biophys. Res. Commun. 167:1326-1332(1990).
Okano K.,et al.J. Biochem. 102:13-16(1987).
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