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IGF-BP3, human recombinant protein
Insulin-like Growth Factor-Binding Protein 3, Growth-hormone-dependant binding protein
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P17936 |
|---|---|
| Calculated MW | 28.8 kDa |
| Gene ID | 3486 |
|---|---|
| Gene Symbol | IBP3 |
| Other Names | Insulin-like Growth Factor-Binding Protein 3, Growth-hormone-dependant binding protein |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥98% |
| Assay2&Purity2 | HPLC; ≥98% |
| Recombinant | Yes |
| Results | <0.2 mg/ml |
| Sequence | AFLVEKTSTE VQCKGGNVCV QAQDRYYNSS CSKWACVPCR VRS |
| Application Notes | Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and store at 4°C for 1 week or –20°C for future use. |
| Format | Lyophilized protein |
| Storage | -20°C; Sterile filtered and lyophilized from 20 mM HCl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Human IGF-BP3, also known as growth-hormone-dependant binding protein, is a 28.9 kDa cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals. In addition to its ability to modulate the activity of IGF-I and IGF-2, IGF-BP3 also exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF, and EGF. Recombinant human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues.
References
Wood W.I.,et al.Mol. Endocrinol. 2:1176-1185(1988).
Cubbage M.L.,et al.J. Biol. Chem. 265:12642-12649(1990).
Thweatt R.,et al.DNA Seq. 4:43-46(1993).
Hillier L.W.,et al.Nature 424:157-164(2003).
Scherer S.W.,et al.Science 300:767-772(2003).
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