Granzyme B, human recombinant protein (Insect)
GranzymeB, Granzyme-2, T-cell serine protease 1-3E, Cytotoxic T-lymphocyte proteinase 2, Lymphocyte
|Calculated MW||32 kDa|
|Gene Symbol||Granzyme B|
|Other Names||GranzymeB, Granzyme-2, T-cell serine protease 1-3E, Cytotoxic T-lymphocyte proteinase 2, Lymphocyte protease, SECT, Cathepsin G-like 1, CTSGL1, CTLA-1, Fragmentin-2, Human lymphocyte protein, HLP, C11|
|Results||≥40 units/ µg|
|Application Notes||Use 50 µl sterile D.I. water to dissolve 5 µg protein to a final conc of 0.1 µg protein/ µl.|
|Storage||-70°C; Lyophilized from 20 mM HEPES buffer at pH 7.5.|
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Provided below are standard protocols that you may find useful for product applications.
Granzyme B (GZMB) is a serine protease stored in granules of activated cytotoxic T cells and NK cells. Upon target cell contact, granzyme B is directionally exocytosed and assisted by perforin, enters the target cell. With its unique substrate specificity (granzyme B cleaves after Asp), granzyme B processes and activates various pro-caspases thereby inducing apoptosis in the target cell.
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