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Granzyme B, human recombinant protein (Insect)
GranzymeB, Granzyme-2, T-cell serine protease 1-3E, Cytotoxic T-lymphocyte proteinase 2, Lymphocyte
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | AAA75490 |
|---|---|
| Calculated MW | 32 kDa |
| Gene ID | 181186 |
|---|---|
| Gene Symbol | Granzyme B |
| Other Names | GranzymeB, Granzyme-2, T-cell serine protease 1-3E, Cytotoxic T-lymphocyte proteinase 2, Lymphocyte protease, SECT, Cathepsin G-like 1, CTSGL1, CTLA-1, Fragmentin-2, Human lymphocyte protein, HLP, C11 |
| Gene Source | Human |
| Source | Insect cells |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Results | ≥40 units/ µg |
| Application Notes | Use 50 µl sterile D.I. water to dissolve 5 µg protein to a final conc of 0.1 µg protein/ µl. |
| Format | Lyophilized protein |
| Storage | -70°C; Lyophilized from 20 mM HEPES buffer at pH 7.5. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Granzyme B (GZMB) is a serine protease stored in granules of activated cytotoxic T cells and NK cells. Upon target cell contact, granzyme B is directionally exocytosed and assisted by perforin, enters the target cell. With its unique substrate specificity (granzyme B cleaves after Asp), granzyme B processes and activates various pro-caspases thereby inducing apoptosis in the target cell.
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